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| Portfolio Companies (By
Industry) |
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Aesthetic Sciences Corporation
 Focused on aesthetic medicine and incontinence

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Aesthetic Sciences Corporation
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Apnex Medical, Inc.
 Developing a device-based treatment for obstructive sleep apnea

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Applied Molecular Evolution, Inc.
 Gene evolution technology to optimize proteins for drug and industrial use

Acquired by Eli Lilly & Co.
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Applied Molecular Evolution, Inc.
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Asmacure, Inc.
 Developing therapeutics for the treatment of asthma

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Asmacure, Inc.
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Athena Neurosciences, Inc.
 Development of diagnostics and therapeutics for Alzheimer's Disease

Acquired by Elan Corporation
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Athena Neurosciences, Inc.
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Auxeris Therapeutics, Inc.
 Osteoporosis drug development

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Biomagnetic Technologies Inc.
 Instrumentation for ultra-sensitive magnetic measurement

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Biomagnetic Technologies Inc.
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British Biotech
 Diversified life-sciences company developing both drugs and research products

Merged with Vernalis pls
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British Biotech
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Calixa Therapeutics, Inc.
 Focused on developing, acquiring and commercializing hospital-based anti-infective therapies

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Calixa Therapeutics, Inc.
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Ciblex Corporation
 Development of drugs that impact protein trafficking for use in proliferative disorders

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CoDa Therapeutics, Inc.
 Development and commercialization of wound care therapeutics based on gap junction modulation

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CoLucid Pharmaceuticals, Inc.
 Developing innovative therapies to treat CNS disorders

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Creative Biomolecules, Inc.
 Development of regenerative medicines

Merged into Curis, Inc.
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Creative Biomolecules, Inc.
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DiObex, Inc.
 Development of drugs to improve the management of diabetic patients

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Dura Pharmaceuticals, Inc.
 Specialty pharmaceutical company focused on respiratory drugs

Acquired by Elan Corporation
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Dura Pharmaceuticals, Inc.
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