Domain Associates, LLC

Portfolio Companies (By Industry)

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		3F Therapeutics, Inc. Devices to treat heart valve disorders Acquired by ATS Medical, Inc.; Acquired by Medtronic

		Achaogen, Inc. Pursuing unique strategies to prevent drug resistance

		Achillion Pharmaceuticals, Inc. Dedicated to bringing important new treatments to patients wih infectious disease

		Acureon Pharmaceuticals, Inc. Acquire and market drugs focused on infectious diseases, transplant and ICU

		Adynxx, Inc. Focused on the treatment of acute and chronic pain

		Aesthetic Sciences Corporation Focused on aesthetic medicine and incontinence
Aesthetic Sciences Corporation

		Afferent Pharmaceuticals, Inc. Focused on developing first-in-class medicines to treat pain

		Aldexa Therapeutics, Inc. Developing novel therapeutics for the treatment of eye diseases

		Align Technology, Inc. Invisalign® invisible braces

		Alimera Sciences, Inc. Development and marketing of in-licensed ophthalmology products

		Altair Therapeutics, Inc. Developing novel therapeutics to treat human respiratory diseases

		Altea Therapeutics Corporation Delivery of drugs across the skin

		Amgen Inc. Focused on products for supportive cancer care, inflammation, nephrology and bone disease

		Amylin Pharmaceuticals, Inc. Development of drugs to treat metabolic diseases

		Ansata Therapeutics, Inc. Drug development utilizing cell targeting technology

		Apnex Medical, Inc. Developing a device-based treatment for obstructive sleep apnea

		Applied Biosystems Technology solutions for DNA, RNA, protein, and small molecule analysis Acquired by Perkin Elmer; merged with Invitrogen to form Life Technologies

		Applied Molecular Evolution, Inc. Gene evolution technology to optimize proteins for drug and industrial use Acquired by Eli Lilly & Co.
Applied Molecular Evolution, Inc.

		Applied Proteomics, Inc. Developing protein biomarkers to improve healthcare and drug development

		Ariosa Diagnostics, Inc. Focused on providing early, non-invasive, and accurate prenatal diagnostic tests for fetal health

		Ascenta Therapeutics, Inc. Anti-cancer drug development

		Asmacure, Inc. Developing therapeutics for the treatment of asthma

		Astute Medical, Inc. Developing innovative, high value, biomarker solutions for the acute hospital setting

		Athena Neurosciences, Inc. Development of diagnostics and therapeutics for Alzheimer's Disease Acquired by Elan Corporation
Athena Neurosciences, Inc.

		AtheroGenics, Inc. Discovery and development of drugs for inflammatory diseases

		aTyr Pharma, Inc. Developing Physiocrines, a novel class of naturally occuring biologics, for human therapeutics

		Aurora Biosciences Corporation Automation to facilitate drug discovery processes Acquired by Vertex Pharmaceuticals
Aurora Biosciences Corporation

		Auxeris Therapeutics, Inc. Osteoporosis drug development

		Benvenue Medical, Inc. Developing devices for the treatment of back pain

		Biomagnetic Technologies Inc. Instrumentation for ultra-sensitive magnetic measurement
Biomagnetic Technologies Inc.

		BioNano Genomics, Inc. Developing technologies for analysis of large biological molecules

		Biosite Diagnostics, Inc. Discovery, development and marketing of rapid diagnostics Acquired by Alere, Inc.

		BioVascular, Inc. Developing solutions for reducing inflammation and thrombosis

		BiPar Sciences, Inc. Developing and commercializing potential new classes of tumor-selective drugs Acquired by sanofi-aventis

		British Biotech Diversified life-sciences company developing both drugs and research products Merged with Vernalis pls
British Biotech

		Cabrellis Pharmaceuticals Corporation Development of important therapies for the treatment of cancer Acquired by Pharmion Corporation; Acquired by Celgene

		Cadence Pharmaceuticals, Inc. Development and marketing of acute care drugs with an initial focus on anti-infectives

		Cadent Medical Corporation Life-saving external defibrillators Acquired by Cardiac Science, Inc.
Cadent Medical Corporation

		Calixa Therapeutics, Inc. Focused on developing, acquiring and commercializing hospital-based anti-infective therapies Acquired by Cubist Pharmaceuticals, Inc.

		Cardiac Science Corporation Life-saving external defibrillators

		CardioDynamics International Corporation Noninvasive digital heart monitoring devices

		CardioPolymers, Inc. Novel therapies for diseases of cardiac conduction Merged with Lonestar Heart, Inc.

		CareCentric Solutions, Inc. Information systems for the home care industry Acquired by Simione Central Holdings (renamed Care Centric); Acquired by Mediware

		Carticept Medical, Inc. Development and sales of therapeutically related medical devices

		Cartiva, Inc. Development of medical devices to treat knee and small joint disease
Cartiva, Inc.

		Celator Pharmaceuticals, Inc. Development of proprietary fixed dose combinations of chemotherapeutic agents for cancer treatment

		Celladon Corporation Developing treatments for cardiovascular diseases through molecular cardiology

		Cerexa, Inc. Focused on developing, acquiring and commercializing hospital-based anti-infective therapies Acquired by Forest Laboratories, Inc.

		Ciblex Corporation Development of drugs that impact protein trafficking for use in proliferative disorders

		Clovis Oncology, Inc. Focused on acquiring, developing and commercializing innovative anti-cancer agents

		CoCensys, Inc. Development of CNS drugs targeted at novel CNS receptors Acquired by Purdue Pharma
CoCensys, Inc.

		CoDa Therapeutics, Inc. Development and commercialization of wound care therapeutics based on gap junction modulation

		CoLucid Pharmaceuticals, Inc. Developing innovative therapies to treat CNS disorders

		Conforma Therapeutics Corporation Anti-cancer drug development Acquired by Biogen IDEC

		Connetics Corporation Development and marketing of dermatology drugs Acquired by Stiefel Laboratories, Inc.

		Corridor Pharmaceuticals, Inc. Developing therapeutics for vascular and pulmonary indications

		Corthera, Inc. Development of Relaxin for various indications Acquired by Novartis Pharmaceuticals Corporation

		Cortria Corporation Developing safe and well-tolerated medicines to fight cardiovascular disease Acquired by Pharmena SA

		Cotera, Inc. Developing new and innovative orthopedic devices
Cotera, Inc.

		Creative Biomolecules, Inc. Development of regenerative medicines Merged into Curis, Inc.
Creative Biomolecules, Inc.

		Cytovia, Inc. Drug screening technology using proprietary apoptosis assays Acquired by Maxim Pharmaceuticals, Inc.; Acquired by EpiCept Corporation
Cytovia, Inc.

		DIANON Sytems Inc. Provides anatomic and clinical pathology, patient information, and business solutions Acquired by Laboratory Corporation of America

		Dicerna Pharmaceuticals, Inc. Developing RNA dicer substrates to treat a variety of diseases

		DiObex, Inc. Development of drugs to improve the management of diabetic patients

		DNX Corporation Development of in vitro and in vivo biological models Merged with BioClin to form Chrysalis International Corporation, subsequently acquired by Phoenix International Life Sciences, part of MDS Pharma
DNX Corporation

		Domain AntiBacterial Acquisition Corporation In-licensing of anti-infective drugs Acquired by Peninsula Pharmaceuticals, Inc.; Acquired by Johnson & Johnson
Domain AntiBacterial Acquisition Corporation

		Domain Elite Holdings Ltd. A unique collaboration designed to create businesses in China
Domain Elite Holdings Ltd.

		DRI Holdings Limited Formed in conjuction with Rusnano to provide funding for Domain companies and establish NovaMedica

		Dura Pharmaceuticals, Inc. Specialty pharmaceutical company focused on respiratory drugs Acquired by Elan Corporation
Dura Pharmaceuticals, Inc.

		Durata Therapeutics, Inc. Development of Dalbavancin, a glycopeptide anti-bacterial agent

		Eddingpharm International Holdings Limited Marketing oncology products in China

		Embrex, Inc. Unique delivery system for poultry vaccines and therapeutics Acquired by Pfizer Animal Health

		Epic Sciences, Inc. Developing new diagnostics for management of cancer

		ESP Pharma, Inc. Acquires & markets acute care products Acquired by Protein Design Labs, Inc.

		Esperion Therapeutics, Inc. Developing pharmaceutical products for the treatment of cardiovascular and metabolic diseases

		Esprit Pharma, Inc. Acquisition, development and marketing of drugs for the urology and OB-GYN physician communities Acquired by Allergan, Inc.

		Eunoe, Inc. Device to treat Alzheimer's disease

		Evoke Pharma, Inc. Acquisition and development of proprietary products for the treatment of gastrointestinal diseases

		Exelixis, Inc. Genomics-based drug discovery

		Five Prime Therapeutics, Inc. Expression and screening of all secreted proteins to find relevant protein therapeutics

		Focal, Inc. Biodegradable materials for the prevention of surgical adhesions Acquired by Genzyme BioSurgery
Focal, Inc.

		Foundry Newco XII, Inc. (d/b/a Twelve) An incubator focused on developing the next generation of medical device innovations
Foundry Newco XII, Inc. (d/b/a Twelve)

		Fractyl Laboratories, Inc. Developing device based treatment for chronic disease

		Fusion Medical Technologies, Inc. Biomaterial for use in surgical procedures to prevent adhesions Acquired by Baxter Healthcare Corporation
Fusion Medical Technologies, Inc.

		GelTex Pharmaceuticals, Inc. Polymer technology for drugs that stay in the GI tract and remove toxins Acquired by Genzyme
GelTex Pharmaceuticals, Inc.

		GeneOhm Sciences, Inc. Molecular diagnostics Acquired by Becton, Dickinson and Company

		GenQuest, Inc. Gene identification for diagnostic and therapeutic applications Acquired by Corixa Corporation; Acquired by GlaxoSmithKline
GenQuest, Inc.

		Gensia Pharmaceuticals Inc. Development of drugs to treat cardiovascular diseases Merged into Sicor; Acquired by Teva Pharmaceuticals
Gensia Pharmaceuticals Inc.

		Genta Incorporated Development of antisense therapeutics

		GenVault Corporation High capacity DNA storage systems Acquired by IntegenX, Inc.

		Geron Corporation Discovery of mechanisms and therapeutics that impact the aging process

		GI Dynamics, Inc. Device to treat obesity

		Glaukos Corporation Device to treat glaucoma

		GlycoDesign Development of novel therapeutics for treatment of cancer, infectious diseases and inflammation Acquired by Inflazyme
GlycoDesign

		Goodwell Technologies, Inc. IT to allow for remote doctor-patient interaction

		Gynecare, Inc. Medical devices for women's healthcare Acquired by Johnson & Johnson

		Helixis, Inc. Developing a molecular diagnostic testing platform for use in diverse physical locations Acquired by Illumina, Inc.

		Imagine Pharmaceuticals, Inc. Technology to facilitate delivery of drugs to the brain

		Imagyn Medical, Inc. Medical devices for gynecological indications Acquired by UroHealth, renamed Imagyn Medical Technologies, Inc.
Imagyn Medical, Inc.

		Immune Control, Inc. Developing drugs to stop undesirable proliferation of immune cells Merged with Corridor Pharmaceuticals, Inc.

		Immunex Corporation Focused on products for rheumatoid arthritis, acute nonlymphocytic leukemia and pain Acquired by Amgen

		Inspire Pharmaceuticals, Inc. Drug development for ophthalmic and respiratory diseases Acquired by Merck & Co.

		IntegenX Inc. Developing equipment for molecular diagnostics

		IntraLase Corporation Devices for laser correction of vision Acquired by Advanced Medical Optics, Inc., Acquired by Abbott Laboratories

		Iomai Corporation Transdermal vaccines Acquired by Intercell AG

		Ista Pharmaceuticals, Inc. Drug development for ophthalmic diseases Acquired by Bausch & Lomb

		Kalidex Pharmaceuticals, Inc. Providing next-generation anti-infective therapies to the marketplace

		Kona Medical, Inc. Developing methods to non-invasively inhibit or albate nerves

		Konova, Inc. Anti-obesity drug development
Konova, Inc.

		LaJolla Pharmaceutical Company Development of therapeutics for antibody-related disorders

		Landec Corporation Crystallizable polymers for a variety of medical and industrial applications

		Lithera, Inc. Developing products for aesthetic medicine to address both medical and lifestyle indications

		Lumisys, Inc. High-performance electro-optical systems for medical imaging Acquired by Eastman Kodak

		Marinus Pharmaceuticals, Inc. Development of therapeutics for treatment of CNS disorders and pain

		Meritage Pharma, Inc. Developing drugs for gastrointestinal diseases

		Microgon Inc. Hollow-fiber membrane filters for use in research laboratories Acquired by Spectrum Laboratories
Microgon Inc.

		Microsurge Improved instrumentation for minimally invasive surgery Acquired by UroHealth, renamed Imagyn Medical Technologies, Inc.
Microsurge

		MicroVention, Inc. Interventional neurology devices Acquired by Terumo Corporation

		MIGENIX Inc. Development of drugs for the prevention and treatment of infectious diseases

		Miramar Labs, Inc. Developing devices for aesthetic indications

		MitoKor Discovery and development of drugs for mitochondrial diseases Acquired by Micrologix Biotech Inc. (now MIGENIX Inc.)

		Molecular Dynamics Use of optical technology to automate laboratory processes Acquired by Amersham Pharmacia Biotech
Molecular Dynamics

		Molecular Staging, Inc. Biomarker discovery utilizing novel DNA/RNA amplification technology Acquired by Qiagen

		Nanothera Corporation Developing safer parenteral products for hospital use

		Neose Technologies, Inc. Enhancement of drugs by glcyosylation Assets sold to Novo Nordisk & BioGeneriX

		Neuralieve, Inc. Developing a non-invasive medical device to treat migraine headaches

		NeuroPace, Inc. Device to treat epilepsy

		Nina Biotherapeutics, Inc. Developing therapies to combat cachexia in cancer patients that improve quality of life & survival
Nina Biotherapeutics, Inc.

		Northstar Neuroscience, Inc. Electrical stimulation to treat neurological defects

		NovaCardia, Inc. Cardiovascular drug development Acquired by Merck & Co., Inc.

		Novacea, Inc. Anti-cancer drug development Merged into Transcept Pharmaceuticals, Inc.

		Novadigm Therapeutics, Inc. Developing vaccines and therapeutics to prevent and treat infectious diseases

		Novalar Pharmaceuticals, Inc. Development of dental medications

		NPS Pharmaceuticals, Inc. Development of drugs for bone, GI, and CNS diseases

		Nuon Therapeutics, Inc. Developing medicines to treat autoimmune disease

		NuVasive, Inc. Devices to assist in spinal surgery

		Obalon Therapeutics, Inc. Developing an orally available intragastric balloon for the treatment of obesity

		Oceana Therapeutics, Inc. Acquire and market drugs Acquired by Salix Pharmaceuticals, Inc.

		Ocera Therapeutics, Inc. Development of drugs to treat gastrointestinal diseases

		OmniSonics Medical Technologies, Inc. Device to remove vascular occlusions

		OncoTherapeutics, Inc. Cancer diagnostics and therapeutics based on Kallikrein family of proteins Acquired by Biomira Inc., now Oncothyreon
OncoTherapeutics, Inc.

		Onux Medical, Inc. Minimally invasive surgical tools Acquired by Davol, Inc., a subsidiary of C.R. Bard, Inc.

		Onyx Pharmaceuticals, Inc. Anti-cancer drug development

		Optherion, Inc. Developing therapeutics for diseases involving the complement system, with an initial focus on AMD

		OraPharma, Inc. Development of dental medications Acquired by Johnson & Johnson

		Oraya Therapeutics, Inc. Developing a radiation-based treatment for wet AMD

		Orexigen Therapeutics, Inc. Anti-obesity drug development

		Origin Medsystems Inc. Instruments and devices for minimally invasive surgery Acquired by Eli Lilly/Guidant; Acquired by Boston Scientific
Origin Medsystems Inc.

		Orqis Medical Corporation Device to treat congestive heart failure

		Otonomy, Inc. Developing novel drug therapies for disorders of the inner and middle ear

		ParinGenix, Inc. Developing a proprietary, modified form of heparin to treat a range of inflammatory diseases

		Peninsula Pharmaceuticals, Inc. Anti-infective drug development Acquired by Johnson & Johnson

		Pharmion Corporation Acquires and markets hematology products Acquired by Celgene Corporation

		Pinta Biotherapeutics, Inc. Developing therapies to reverse protein energy wasting in end-stage renal disease
Pinta Biotherapeutics, Inc.

		Pointshare Corporation Community-based healthcare intra and extranet solutions

		ProteinSimple Lab instrumentation enabling analysis of cell signaling activity

		Proxima Therapeutics, Inc. Novel system to deliver radiation to treat cancer Acquired by Cytyc Corporation; Acquired by Hologic, Inc.

		Receptor BioLogix, Inc. Developing a new class of protein therapeutics called Intron Fusion Proteins

		Regado Biosciences, Inc. Developing rapidly reversible anti-clotting medications

		Resound Corporation Revolutionary technology for hearing aids Merged into GN ReSound

		REVA Medical, Inc. Resorbable stent technology

		ReVision Optics, Inc. Developing new technologies, products and procedures aimed at the correction of presbyopia

		RiboGene, Inc. Therapeutics based on control of protein translation Merged with Cypros to form Questcor
RiboGene, Inc.

		RightCare Solutions, Inc. An evidence-based technology company specializing in discharge planning and readmission management

		ROX Medical, Inc. Device to treat chronic obstructive pulmonary disease

		Ruxton Pharmaceuticals, Inc. Proprietary assays to discover and develop drugs to treat ALS

		Santa Maria Biotherapeutics, Inc. Developing therapies for ovarian cancer that simultaneously reduce tumor burden & mitigate cachexia
Santa Maria Biotherapeutics, Inc.

		Santarus, Inc. GI drug development using novel formulations

		Sebacia, Inc. Developing novel technology to address a large unmet need in dermatology

		Selective Genetics, Inc. Site-specific gene therapies primarily for tissue repair

		Senomyx, Inc. Discovery and development of flavor enhancing chemicals

		SenoRx, Inc. Surgical tools for breast disease Acquired by C.R. Bard, Inc.

		Sepracor, Inc. Separation technology applied to drug discovery Merged with Dainippon Sumitomo to form Sunovion

		Sequel Pharmaceuticals, Inc. Cardiovascular drug development

		Sequent Medical, Inc. Dedicated to the development of innovative devices to treat neurovascular disease conditions

		Sera Prognostics, Inc. Developing diagnostic tests for early prediction of preterm birth and other pregnancy complications

		Sievers Instruments, Inc. Novel detectors for gas chromatography Acquired by Ionics; Acquired by GE Infrastructure
Sievers Instruments, Inc.

		SkinMedica, Inc. Acquires & markets dermatologic products Acquired by Allergan, Inc.

		Small Molecule Therapeutics, Inc. Discovery of small molecule drugs based on proprietary screening technology Acquired by MorphoChem AG

		Somaxon Pharmaceuticals, Inc. Development of psychiatric drugs

		Sonexa Therapeutics, Inc. Developing therapeutics for the treatment of Alzheimer's disease

		Syndax Pharmaceuticals, Inc. Development and commercialization of novel cancer therapies

		Tandem Diabetes Care, Inc. Developing novel devices for the treatment of diabetes

		TargetRx, Inc. Information services for the pharmaceutical industry Acquired by ImpactRx, Inc.

		Tobira Therapeutics, Inc. Dedicated to the clinical development of antiviral products

		Tragara Pharmaceuticals, Inc. Development of proprietary drugs for the treatment of cancer and inflammation-related disorders

		Trega Biosciences, Inc. Combinatorial chemistry technology used to discover novel therapeutics Acquired by LION bioscience
Trega Biosciences, Inc.

		Trimeris, Inc. Novel HIV therapeutics Merged with Synageva

		Univax Biologics Vaccines to stimulate the plasma donor production of immunoglobulins Acquired by Nabi Pharmaceuticals; Merged with Biota Pharmaceuticals, Inc.
Univax Biologics

		US Bioscience, Inc. Acquisition and marketing of cancer drugs Acquired by MedImmune; Acquired by Astra Zeneca

		Valley Forge Pharmaceuticals, Inc. Anti-myopia drug development

		Vanda Pharmaceuticals, Inc. Analysis of genetic, genomic and clinical date to rescue "failed" drugs

		Vascular Architects, Inc. Novel stent technology Acquired by LeMaitre Vascular

		Vascular Therapeutics, Inc. Biopharmaceuticals for the prevention and treatment of vascular disease Acquired by GlycoDesign; Acquired by Inflazyme
Vascular Therapeutics, Inc.

		VenPro Corporation Intravascular valve technology Acquired by 3F Therapeutics; Acquired by ATS Medical; Acquired by Medtronic

		VentiRx Pharmaceuticals, Inc. Developing novel drugs for the treatment of cancer, infectious, respiratory and autoimmune diseases.

		Veracyte, Inc. Developing a molecular-based thyroid cancer diagnostic that permits diagnoses without surgery

		Verus Pharmaceuticals, Inc. Development and marketing of pediatric focused therapeutics

		Viagene Inc. Gene manipulation technology for the discovery of anti-infective therapies Acquired by Chiron; Acquired by Novartis
Viagene Inc.

		Vista Medical Technologies, Inc. Visualization technology to aid in surgical procedures

		Vivus, Inc. Therapeutics to treat sexual dysfunction

		Volcano Corporation Detection and treatment of vascular disease

		Xcel Pharmaceuticals, Inc. Acquires & markets neurology products Acquired by Valeant Pharmaceuticals International

		X-Ceptor Therapeutics, Inc. Drug development focused on orphan nuclear receptors Acquired by Exelixis, Inc.

		Zogenix, Inc. Development and commercialization of medicines to treat CNS disorders and pain

		Zyga Technology, Inc. Developing therapies for the treatment of back pain