Domain Associates, LLC

Portfolio Companies (Active)

		Achaogen, Inc. Pursuing unique strategies to prevent drug resistance

		Achillion Pharmaceuticals, Inc. Dedicated to bringing important new treatments to patients wih infectious disease

		Adynxx, Inc. Focused on the treatment of acute and chronic pain

		Afferent Pharmaceuticals, Inc. Focused on developing first-in-class medicines to treat pain

		Aldexa Therapeutics, Inc. Developing novel therapeutics for the treatment of eye diseases

		Alimera Sciences, Inc. Development and marketing of in-licensed ophthalmology products

		Applied Proteomics, Inc. Developing protein biomarkers to improve healthcare and drug development

		Ariosa Diagnostics, Inc. Focused on providing early, non-invasive, and accurate prenatal diagnostic tests for fetal health

		Ascenta Therapeutics, Inc. Anti-cancer drug development

		Asmacure, Inc. Developing therapeutics for the treatment of asthma

		Astute Medical, Inc. Developing innovative, high value, biomarker solutions for the acute hospital setting

		aTyr Pharma, Inc. Developing Physiocrines, a novel class of naturally occuring biologics, for human therapeutics

		Benvenue Medical, Inc. Developing devices for the treatment of back pain

		BioNano Genomics, Inc. Developing technologies for analysis of large biological molecules

		Cadence Pharmaceuticals, Inc. Development and marketing of acute care drugs with an initial focus on anti-infectives

		Carticept Medical, Inc. Development and sales of therapeutically related medical devices

		Cartiva, Inc. Development of medical devices to treat knee and small joint disease
Cartiva, Inc.

		Celator Pharmaceuticals, Inc. Development of proprietary fixed dose combinations of chemotherapeutic agents for cancer treatment

		Clovis Oncology, Inc. Focused on acquiring, developing and commercializing innovative anti-cancer agents

		CoDa Therapeutics, Inc. Development and commercialization of wound care therapeutics based on gap junction modulation

		CoLucid Pharmaceuticals, Inc. Developing innovative therapies to treat CNS disorders

		Corridor Pharmaceuticals, Inc. Developing therapeutics for vascular and pulmonary indications

		Cotera, Inc. Developing new and innovative orthopedic devices
Cotera, Inc.

		Dicerna Pharmaceuticals, Inc. Developing RNA dicer substrates to treat a variety of diseases

		Domain Elite Holdings Ltd. A unique collaboration designed to create businesses in China
Domain Elite Holdings Ltd.

		DRI Holdings Limited Formed in conjuction with Rusnano to provide funding for Domain companies and establish NovaMedica

		Durata Therapeutics, Inc. Development of Dalbavancin, a glycopeptide anti-bacterial agent

		Eddingpharm International Holdings Limited Marketing oncology products in China

		Epic Sciences, Inc. Developing new diagnostics for management of cancer

		Esperion Therapeutics, Inc. Developing pharmaceutical products for the treatment of cardiovascular and metabolic diseases

		Evoke Pharma, Inc. Acquisition and development of proprietary products for the treatment of gastrointestinal diseases

		Five Prime Therapeutics, Inc. Expression and screening of all secreted proteins to find relevant protein therapeutics

		Foundry Newco XII, Inc. (d/b/a Twelve) An incubator focused on developing the next generation of medical device innovations
Foundry Newco XII, Inc. (d/b/a Twelve)

		Fractyl Laboratories, Inc. Developing device based treatment for chronic disease

		GI Dynamics, Inc. Device to treat obesity

		Glaukos Corporation Device to treat glaucoma

		IntegenX Inc. Developing equipment for molecular diagnostics

		Kona Medical, Inc. Developing methods to non-invasively inhibit or albate nerves

		Lithera, Inc. Developing products for aesthetic medicine to address both medical and lifestyle indications

		Marinus Pharmaceuticals, Inc. Development of therapeutics for treatment of CNS disorders and pain

		Meritage Pharma, Inc. Developing drugs for gastrointestinal diseases

		Miramar Labs, Inc. Developing devices for aesthetic indications

		NeuroPace, Inc. Device to treat epilepsy

		Nina Biotherapeutics, Inc. Developing therapies to combat cachexia in cancer patients that improve quality of life & survival
Nina Biotherapeutics, Inc.

		Novadigm Therapeutics, Inc. Developing vaccines and therapeutics to prevent and treat infectious diseases

		Obalon Therapeutics, Inc. Developing an orally available intragastric balloon for the treatment of obesity

		Ocera Therapeutics, Inc. Development of drugs to treat gastrointestinal diseases

		Oraya Therapeutics, Inc. Developing a radiation-based treatment for wet AMD

		Orexigen Therapeutics, Inc. Anti-obesity drug development

		Otonomy, Inc. Developing novel drug therapies for disorders of the inner and middle ear

		ParinGenix, Inc. Developing a proprietary, modified form of heparin to treat a range of inflammatory diseases

		Pinta Biotherapeutics, Inc. Developing therapies to reverse protein energy wasting in end-stage renal disease
Pinta Biotherapeutics, Inc.

		ProteinSimple Lab instrumentation enabling analysis of cell signaling activity

		Regado Biosciences, Inc. Developing rapidly reversible anti-clotting medications

		REVA Medical, Inc. Resorbable stent technology

		ReVision Optics, Inc. Developing new technologies, products and procedures aimed at the correction of presbyopia

		RightCare Solutions, Inc. An evidence-based technology company specializing in discharge planning and readmission management

		ROX Medical, Inc. Device to treat chronic obstructive pulmonary disease

		Santa Maria Biotherapeutics, Inc. Developing therapies for ovarian cancer that simultaneously reduce tumor burden & mitigate cachexia
Santa Maria Biotherapeutics, Inc.

		Sebacia, Inc. Developing novel technology to address a large unmet need in dermatology

		Sequent Medical, Inc. Dedicated to the development of innovative devices to treat neurovascular disease conditions

		Sera Prognostics, Inc. Developing diagnostic tests for early prediction of preterm birth and other pregnancy complications

		Sonexa Therapeutics, Inc. Developing therapeutics for the treatment of Alzheimer's disease

		Syndax Pharmaceuticals, Inc. Development and commercialization of novel cancer therapies

		Tandem Diabetes Care, Inc. Developing novel devices for the treatment of diabetes

		Tobira Therapeutics, Inc. Dedicated to the clinical development of antiviral products

		Tragara Pharmaceuticals, Inc. Development of proprietary drugs for the treatment of cancer and inflammation-related disorders

		VentiRx Pharmaceuticals, Inc. Developing novel drugs for the treatment of cancer, infectious, respiratory and autoimmune diseases.

		Veracyte, Inc. Developing a molecular-based thyroid cancer diagnostic that permits diagnoses without surgery

		Zogenix, Inc. Development and commercialization of medicines to treat CNS disorders and pain

		Zyga Technology, Inc. Developing therapies for the treatment of back pain